Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Amitriptyline Elavil An increased risk of QT interval prolongation Details Ofloxacin Sertraline An increased risk of QT interval prolongation Details Ofloxacin Buprenorphine Belbuca An increased risk of QT interval prolongation Details Ofloxacin Relugolix Orgovyx Increased risk of QT interval prolongation Details Ofloxacin Acarbose Prandase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Ofloxacin Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Ofloxacin Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Ofloxacin Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Ofloxacin Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Ofloxacin Azithromycin AzaSite An increased risk of QT interval prolongation Details Ofloxacin Alfuzosin UroXatral An increased risk of QT interval prolongation Details Ofloxacin Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Anagrelide Agrylin Increased anagrelide exposure and increased risk of QT interval prolongation Details Ofloxacin Bedaquiline Sirturo Increased risk of QT interval prolongation Details Ofloxacin Budesonide Entocort An increased risk of tendon rupture Details Ofloxacin Budesonide Nasal Spray Rhinocort An increased risk of tendon rupture Details Ofloxacin Budesonide Oral Inhalation Pulmicort An increased risk of tendon rupture Details Ofloxacin Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Chloroquine Aralen® An increased risk of QT interval prolongation Details Ofloxacin Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Dasatinib Phyrago An increased risk of QT interval prolongation Details Ofloxacin Deflazacort Emflaza An increased risk of tendon rupture Details Ofloxacin Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Ofloxacin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Ofloxacin Dexamethasone Injection Decadron An increased risk of tendon rupture Details Ofloxacin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) An increased risk of tendon rupture Details Ofloxacin Disopyramide Norpace An increased risk of QT interval prolongation Details Ofloxacin Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Dolasetron Anzemet An increased risk of QT interval prolongation Details Ofloxacin Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Ofloxacin Dulaglutide Injection Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Encorafenib Braftovi Increased risk of QT interval prolongation Details Ofloxacin Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Ofloxacin Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Flecainide Tambocor® An increased risk of QT interval prolongation Details Ofloxacin Fludrocortisone Acetate Florinef® An increased risk of tendon rupture Details Ofloxacin Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.