Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Fostemsavir Rukobia Increased risk of torsade de pointes Details Ofloxacin Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Ofloxacin Gemifloxacin Factive An increased risk of QT interval prolongation Details Ofloxacin Glasdegib Daurismo Increased risk of QT interval prolongation Details Ofloxacin Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Ofloxacin Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Ofloxacin Granisetron Injection Granisol An increased risk of QT interval prolongation Details Ofloxacin Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Ofloxacin Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Ofloxacin Hydrocortisone Injection A-Hydrocort® An increased risk of tendon rupture Details Ofloxacin Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Ofloxacin Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Ofloxacin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Detemir (Rdna Origin) Injection Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Glulisine (Rdna Origin) Injection Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Ofloxacin Lefamulin Xenleta Increased risk of QT interval prolongation Details Ofloxacin Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Ofloxacin Levofloxacin Levaquin Increased risk of QT interval prolongation Details Ofloxacin Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Ofloxacin Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Liraglutide Injection Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Lixisenatide Injection Adlyxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Ofloxacin Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Ofloxacin Mefloquine Lariam® An increased risk of QT interval prolongation Details Ofloxacin Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ofloxacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ofloxacin Metronidazole Flagyl An increased risk of QT interval prolongation Details Ofloxacin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Ofloxacin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Ofloxacin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Ofloxacin Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Moxifloxacin Avelox Increased risk of QT interval prolongation Details Ofloxacin Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Ofloxacin Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Ofloxacin Nateglinide Starlix® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Octreotide Bynfezia An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.