Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Moderate

Ofloxacin Dexketoprofen An increased risk of seizures Details Ofloxacin Diclofenac Aleve Arthritis Pain An increased risk of seizures Details Ofloxacin Diflunisal Dolobid An increased risk of seizures Details Ofloxacin Dihydroxyaluminum Aminoacetate Decreased oral ofloxacin effectiveness Details Ofloxacin Dihydroxyaluminum Sodium Carbonate Decreased oral ofloxacin effectiveness Details Ofloxacin Dipyrone An increased risk of seizures Details Ofloxacin Droxicam An increased risk of seizures Details Ofloxacin Etofenamate An increased risk of seizures Details Ofloxacin Etoricoxib An increased risk of seizures Details Ofloxacin Felbinac An increased risk of seizures Details Ofloxacin Fepradinol An increased risk of seizures Details Ofloxacin Feprazone An increased risk of seizures Details Ofloxacin Floctafenine An increased risk of seizures Details Ofloxacin Flufenamic Acid An increased risk of seizures Details Ofloxacin Ibuprofen Lysine An increased risk of seizures Details Ofloxacin Indomethacin Indocin An increased risk of seizures Details Ofloxacin Iron Decreased ofloxacin effectiveness Details Ofloxacin Lanthanum Carbonate Fosrenol Reduced bioavailability of quinolone antibiotics Details Ofloxacin Lornoxicam An increased risk of seizures Details Ofloxacin Loxoprofen An increased risk of seizures Details Ofloxacin Lumiracoxib An increased risk of seizures Details Ofloxacin Magaldrate Decreased oral ofloxacin effectiveness Details Ofloxacin Magnesium Carbonate Decreased oral ofloxacin effectiveness Details Ofloxacin Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased oral ofloxacin effectiveness Details Ofloxacin Magnesium Oxide Mag-Ox 400 Decreased oral ofloxacin effectiveness Details Ofloxacin Magnesium Trisilicate Decreased oral ofloxacin effectiveness Details Ofloxacin Morniflumate An increased risk of seizures Details Ofloxacin Nepafenac Ilevro An increased risk of seizures Details Ofloxacin Niflumic Acid An increased risk of seizures Details Ofloxacin Nimesulide An increased risk of seizures Details Ofloxacin Nimesulide Beta Cyclodextrin An increased risk of seizures Details Ofloxacin Oxaprozin Coxanto An increased risk of seizures Details Ofloxacin Oxyphenbutazone An increased risk of seizures Details Ofloxacin Parecoxib An increased risk of seizures Details Ofloxacin Phenylbutazone Equi-Phar An increased risk of seizures Details Ofloxacin Piketoprofen An increased risk of seizures Details Ofloxacin Piroxicam Feldene An increased risk of seizures Details Ofloxacin Proglumetacin An increased risk of seizures Details Ofloxacin Propionic Acid An increased risk of seizures Details Ofloxacin Propyphenazone An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.