Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Ofloxacin Acecainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Ofloxacin Albiglutide Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Alosetron Increased plasma concentration and half-life of alosetron Details Ofloxacin Amiodarone Nexterone An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Ofloxacin Amoxapine An increased risk of QT interval prolongation Details Ofloxacin Apomorphine Apokyn An increased risk of QT interval prolongation Details Ofloxacin Aripiprazole Abilify An increased risk of QT interval prolongation Details Ofloxacin Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Ofloxacin Artemether An increased risk of QT interval prolongation Details Ofloxacin Asenapine Saphris Increased risk of QT interval prolongation Details Ofloxacin Astemizole An increased risk of QT interval prolongation Details Ofloxacin Atazanavir Reyataz An increased risk of QT interval prolongation Details Ofloxacin Azimilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Betamethasone Betavet An increased risk of tendon rupture Details Ofloxacin Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Bupropion Aplenzin Increased risk of seizures Details Ofloxacin Ceritinib Zykadia An increased risk of QT interval prolongation Details Ofloxacin Chlorpromazine An increased risk of QT interval prolongation Details Ofloxacin Chlorpropamide Diabinese® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Ofloxacin Ciprofloxacin An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ofloxacin Citalopram Celexa An increased risk of QT interval prolongation Details Ofloxacin Clarithromycin Biaxin An increased risk of QT interval prolongation Details Ofloxacin Clofazimine An increased risk of QT interval prolongation Details Ofloxacin Clomipramine Anafranil An increased risk of QT interval prolongation and an increased risk of seizures Details Ofloxacin Clothiapine Increased risk of cardiac arrhythmias Details Ofloxacin Clozapine Clozaril Increased risk of QT interval prolongation Details Ofloxacin Corticotropin An increased risk of tendon rupture Details Ofloxacin Cortisone An increased risk of tendon rupture Details Ofloxacin Cosyntropin An increased risk of tendon rupture Details Ofloxacin Crizotinib Xalkori An increased risk of QT interval prolongation Details Ofloxacin Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Ofloxacin Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Ofloxacin Degarelix Firmagon Increased risk of QT interval prolongation Details Ofloxacin Delamanid Increased risk of QT interval prolongation Details Ofloxacin Desflurane Suprane An increased risk of QT interval prolongation Details Ofloxacin Desipramine Norpramin An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.