Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Dexamethasone An increased risk of tendon rupture Details Ofloxacin Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Ofloxacin Domperidone Increased risk of QT interval prolongation Details Ofloxacin Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Ofloxacin Dordaviprone An increased risk of QT interval prolongation Details Ofloxacin Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Droperidol An increased risk of QT interval prolongation Details Ofloxacin Dulaglutide Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Efavirenz An increased risk of QT interval prolongation Details Ofloxacin Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Ofloxacin Escitalopram Lexapro An increased risk of QT interval prolongation Details Ofloxacin Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Ofloxacin Exenatide Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Fexinidazole An increased risk of QT interval prolongation Details Ofloxacin Fingolimod Gilenya Increased risk of QT interval prolongation Details Ofloxacin Fluconazole Diflucan An increased risk of QT interval prolongation Details Ofloxacin Fludrocortisone An increased risk of tendon rupture Details Ofloxacin Fluocortolone An increased risk of tendon rupture Details Ofloxacin Fluoxetine RECONCILE An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Ofloxacin Formoterol Perforomist Increased risk of QT interval prolongation and an increased risk of cardiovascular adverse effects Details Ofloxacin Foscarnet Foscavir Increased risk of QT interval prolongation Details Ofloxacin Fosfomycin Contepo An increased risk of QT interval prolongation Details Ofloxacin Fosphenytoin Cerebyx An increased risk of QT interval prolongation Details Ofloxacin Gatifloxacin Zymaxid An increased risk of QT interval prolongation Details Ofloxacin Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Ofloxacin Gepotidacin Blujepa An increased risk of QT interval prolongation Details Ofloxacin Givinostat Duvyzat Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Glyburide DiaBeta® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Goserelin Increased risk of QT interval prolongation Details Ofloxacin Granisetron An increased risk of QT interval prolongation Details Ofloxacin Halofantrine An increased risk of QT interval prolongation Details Ofloxacin Haloperidol An increased risk of QT interval prolongation Details Ofloxacin Histrelin Supprelin Increased risk of QT interval prolongation Details Ofloxacin Hydroxyzine An increased risk of QT interval prolongation Details Ofloxacin Ibutilide Corvert An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Iloperidone Fanapt An increased risk of QT interval prolongation Details Ofloxacin Imipramine An increased risk of QT interval prolongation Details Ofloxacin Inotuzumab Ozogamicin Besponsa Increased risk of QT interval prolongation Details Ofloxacin Insulin Afrezza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Aspart, Recombinant Fiasp Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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