Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Insulin Bovine Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Degludec Tresiba Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Detemir Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Glulisine Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Insulin Lispro, Recombinant Admelog Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Itraconazole Sporanox An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Ofloxacin Ketoconazole Extina Increased risk of QT interval prolongation Details Ofloxacin Lapatinib Tykerb An increased risk of QT interval prolongation Details Ofloxacin Leuprolide Eligard Increased risk of QT interval prolongation Details Ofloxacin Liraglutide Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Lixisenatide Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Ofloxacin Lofexidine Increased risk of QT interval prolongation Details Ofloxacin Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Lopinavir Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Lumefantrine An increased risk of QT interval prolongation Details Ofloxacin Macimorelin Increased risk of QT interval prolongation Details Ofloxacin Magnesium Sulfate May reduce absorption of fluoroquinolone antibiotics Details Ofloxacin Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Methadone Diskets Increased risk of QT interval prolongation Details Ofloxacin Methylprednisolone Depo-Medrol An increased risk of tendon rupture Details Ofloxacin Mifepristone Korlym An increased risk of QT interval prolongation Details Ofloxacin Milsaperidone An increased risk of QT interval prolongation Details Ofloxacin Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Ofloxacin Mobocertinib Exkivity An increased risk of QT interval prolongation Details Ofloxacin Moricizine An increased risk of QT interval prolongation Details Ofloxacin Nelfinavir Viracept Increased risk of QT interval prolongation Details Ofloxacin Nilotinib Increased risk of QT interval prolongation Details Ofloxacin Norfloxacin An increased risk of QT interval prolongation Details Ofloxacin Nortriptyline An increased risk of QT interval prolongation Details Ofloxacin Olanzapine An increased risk of QT interval prolongation Details Ofloxacin Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Ofloxacin Ondansetron Increased risk of QT interval prolongation Details Ofloxacin Osilodrostat Isturisa Increased risk of QT interval prolongation Details Ofloxacin Osimertinib Tagrisso Increased risk of QT interval prolongation Details Ofloxacin Oxaliplatin Increased risk of QT-interval prolongation Details Ofloxacin Ozanimod Additive effects on heart rate Details Ofloxacin Pacritinib Vonjo® An increased risk of QT interval prolongation Details Ofloxacin Paliperidone Erzofri Increased risk of QT interval prolongation and torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.