Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Panobinostat Farydak Increased risk of QT interval prolongation Details Ofloxacin Paroxetine Paxil An increased risk of QT interval prolongation Details Ofloxacin Pasireotide Signifor Increased risk of QT prolongation Details Ofloxacin Pazopanib Votrient Increased risk of QT interval prolongation Details Ofloxacin Phenobarbital Fidoquel An increased risk of QT interval prolongation Details Ofloxacin Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Ofloxacin Pioglitazone Actos Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Pitolisant Wakix Increased risk of QT interval prolongation Details Ofloxacin Ponesimod Ponvory An increased risk of QT interval prolongation Details Ofloxacin Porfimer Excessive intracellular damage in photosensitized tissues Details Ofloxacin Posaconazole Noxafil An increased risk of QT interval prolongation Details Ofloxacin Pramlintide Symlin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Prednisolone Flo-Pred® An increased risk of tendon rupture Details Ofloxacin Prednisone Deltasone An increased risk of tendon rupture Details Ofloxacin Primidone Mysoline An increased risk of QT interval prolongation Details Ofloxacin Procainamide Procan® An increased risk of QT interval prolongation Details Ofloxacin Prochlorperazine An increased risk of QT interval prolongation Details Ofloxacin Promethazine Phenadoz An increased risk of QT interval prolongation Details Ofloxacin Protriptyline An increased risk of QT interval prolongation Details Ofloxacin Quetiapine Seroquel An increased risk of QT interval prolongation Details Ofloxacin Quinidine Cardioquin® An increased risk of QT interval prolongation Details Ofloxacin Quinine An increased risk of QT interval prolongation Details Ofloxacin Quizartinib Vanflyta An increased risk of QT interval prolongation Details Ofloxacin Ranolazine Aspruzyo An increased risk of QT interval prolongation Details Ofloxacin Rasagiline Azilect Increased rasagiline exposure Details Ofloxacin Repaglinide Prandin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Revumenib Revuforj An increased risk of QT interval prolongation Details Ofloxacin Ribociclib Kisqali An increased risk of QT interval prolongation Details Ofloxacin Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Rosiglitazone Avandia® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Saxagliptin Onglyza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Selpercatinib Retevmo Increased risk of QT interval prolongation Details Ofloxacin Semaglutide Ozempic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Sematilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Sevoflurane Petrem Increased risk of QT interval prolongation Details Ofloxacin Siponimod Mayzent An increased risk of QT interval prolongation Details Ofloxacin Sitagliptin Brynovin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Sodium Phosphate OsmoPrep An increased risk of QT interval prolongation Details Ofloxacin Sodium Phosphate, Dibasic An increased risk of QT interval prolongation Details Ofloxacin Sodium Phosphate, Monobasic An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.