Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Major

Ofloxacin Solifenacin Vesicare An increased risk of QT interval prolongation Details Ofloxacin Sorafenib Nexavar An increased risk of QT interval prolongation Details Ofloxacin Sotalol Betapace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Sulpiride An increased risk of QT interval prolongation Details Ofloxacin Sunitinib Sutent An increased risk of QT interval prolongation Details Ofloxacin Tacrolimus Astagraf An increased risk of QT interval prolongation Details Ofloxacin Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Tamoxifen Nolvadex® An increased risk of QT interval prolongation Details Ofloxacin Tedisamil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Telithromycin An increased risk of QT interval prolongation Details Ofloxacin Tetrabenazine Xenazine An increased risk of QT interval prolongation Details Ofloxacin Tizanidine Increased tizanidine plasma concentrations Details Ofloxacin Tolazamide Tolinase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Tolbutamide Orinase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Toremifene Fareston An increased risk of QT interval prolongation, ventricular tachycardia or an increased risk of torsade de pointes Details Ofloxacin Tramadol ConZip An increased risk of seizure Details Ofloxacin Trazodone Raldesy An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Ofloxacin Triamcinolone Aller-Cort An increased risk of tendon rupture Details Ofloxacin Triclabendazole Egaten An increased risk of QT interval prolongation Details Ofloxacin Trifluoperazine An increased risk of QT interval prolongation Details Ofloxacin Trimipramine An increased risk of QT interval prolongation Details Ofloxacin Triptorelin Increased risk of QT interval prolongation Details Ofloxacin Vandetanib Caprelsa Increased risk of QT interval prolongation Details Ofloxacin Vardenafil Levitra An increased risk of QT interval prolongation Details Ofloxacin Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Ofloxacin Venlafaxine An increased risk of QT interval prolongation Details Ofloxacin Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Ofloxacin Vilanterol An increased risk of QT interval prolongation Details Ofloxacin Vinflunine Increased risk of QT-interval prolongation Details Ofloxacin Voclosporin Lupkynis An increased risk of QT interval prolongation Details Ofloxacin Voglibose Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Voriconazole Vfend An increased risk of QT interval prolongation Details Ofloxacin Warfarin Coumadin An increased risk of bleeding Details Ofloxacin Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Zuclopenthixol An increased risk of QT interval prolongation Details Ofloxacin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Ofloxacin Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.