Orlistat

144 interactions 77 cited references
Also sold as: Alli Alli® Xenical Xenical®
About Orlistat

Orlistat (prescription and nonprescription) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. Orlistat is also used after weight… Read the full Orlistat drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Orlistat Abacavir Ziagen Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Acetazolamide Diamox® Sequels® Reduced efficacy of anticonvulsant Details Orlistat Apixaban Eliquis An increased risk of bleeding Details Orlistat Azathioprine Azasan An increased risk of hepatotoxicity Details Orlistat Betrixaban Bevyxxa® An increased risk of bleeding Details Orlistat Brivaracetam Briviact Reduced efficacy of anticonvulsant Details Orlistat Brivaracetam Injection Briviact Reduced efficacy of anticonvulsant Details Orlistat Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Orlistat Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Orlistat Dabigatran Pradaxa® An increased risk of bleeding Details Orlistat Dabigatran Etexilate An increased risk of bleeding Details Orlistat Dalteparin Injection Fragmin An increased risk of bleeding Details Orlistat Diazepam Nasal Spray Valtoco Reduced efficacy of anticonvulsant Details Orlistat Diazepam Rectal Diastat Reduced efficacy of anticonvulsant Details Orlistat Didanosine Videx® Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Edoxaban Savaysa An increased risk of bleeding Details Orlistat Emtricitabine Emtriva Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Enoxaparin Lovenox An increased risk of bleeding Details Orlistat Enoxaparin Injection Lovenox An increased risk of bleeding Details Orlistat Ethosuximide Zarontin Reduced efficacy of anticonvulsant Details Orlistat Felbamate Felbatol Reduced efficacy of anticonvulsant Details Orlistat Fondaparinux Arixtra An increased risk of bleeding Details Orlistat Fondaparinux Injection Arixtra An increased risk of bleeding Details Orlistat Glimepiride Amaryl An increased risk of hypoglycemia Details Orlistat Glipizide Glucotrol An increased risk of hypoglycemia Details Orlistat Heparin An increased risk of bleeding Details Orlistat Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Orlistat Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Orlistat Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Orlistat Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Orlistat Lacosamide Injection Motpoly Reduced efficacy of anticonvulsant Details Orlistat Lamivudine Epivir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Levetiracetam Elepsia Reduced efficacy of anticonvulsant Details Orlistat Levetiracetam Injection Elepsia Reduced efficacy of anticonvulsant Details Orlistat Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Orlistat Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Orlistat Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Orlistat Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Orlistat Methsuximide Celontin Reduced efficacy of anticonvulsant Details Orlistat Midazolam Nasal Spray Nayzilam Reduced efficacy of anticonvulsant Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.