Orlistat

Name: Orlistat Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

144 interactions 77 cited references

Also sold as: Alli Alli® Xenical Xenical®

About Orlistat

Orlistat (prescription and nonprescription) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. Orlistat is also used after weight… Read the full Orlistat drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Nasal Spray Zonisamide Diazepam Nasal Spray Lacosamide Injection Insulin Glulisine (Rdna Origin) Injection Brivaracetam

139 Major 4 Moderate 1 Minor

All (144) Major (139) Moderate (4) Minor (1)

Moderate

Orlistat Amiodarone Nexterone Reduced amiodarone and its metabolite (desethylamiodarone) exposure and reduced efficacy of amiodarone Details Orlistat Beta Carotene Reduced efficacy of beta-carotene Details Orlistat Linoleic Acid Decreased absorption of linoleic acid Details Orlistat Vitamin E Reduced vitamin E efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.