Orlistat

144 interactions 77 cited references
Also sold as: Alli Alli® Xenical Xenical®
About Orlistat

Orlistat (prescription and nonprescription) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. Orlistat is also used after weight… Read the full Orlistat drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Orlistat Midazolam Injection Nayzilam Reduced efficacy of anticonvulsant Details Orlistat Nevirapine Viramune Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Acenocoumarol An increased risk of bleeding Details Orlistat Acetazolamide Sodium Reduced efficacy of anticonvulsant Details Orlistat Acetohexamide An increased risk of hypoglycemia Details Orlistat Ardeparin An increased risk of bleeding Details Orlistat Argatroban An increased risk of bleeding Details Orlistat Atazanavir Reyataz Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Bemiparin An increased risk of bleeding Details Orlistat Bivalirudin Angiomax An increased risk of bleeding Details Orlistat Cannabidiol Epidiolex Reduced efficacy of anticonvulsant Details Orlistat Carbamazepine Carbatrol Reduced efficacy of anticonvulsant Details Orlistat Cenobamate Xcopri Reduced efficacy of anticonvulsant Details Orlistat Certoparin An increased risk of bleeding Details Orlistat Chlorpropamide Diabinese® An increased risk of hypoglycemia Details Orlistat Clobazam Onfi Reduced efficacy of anticonvulsant Details Orlistat Clonazepam Klonopin Reduced efficacy of anticonvulsant Details Orlistat Clorazepate Tranxene Reduced efficacy of anticonvulsant Details Orlistat Clorazepate Dipotassium Reduced efficacy of anticonvulsant Details Orlistat Cobicistat Tybost Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Cyclosporine Atopica Reduced cycloSPORINE exposure Details Orlistat Dalteparin Fragmin An increased risk of bleeding Details Orlistat Danaparoid An increased risk of bleeding Details Orlistat Darunavir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Desirudin Iprivask An increased risk of bleeding Details Orlistat Diazepam Diastat Reduced efficacy of anticonvulsant Details Orlistat Divalproex Sodium Reduced efficacy of anticonvulsant Details Orlistat Efavirenz Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Elvitegravir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Eslicarbazepine Acetate Aptiom Reduced efficacy of anticonvulsant Details Orlistat Fosamprenavir Lexiva Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Fosphenytoin Cerebyx Reduced efficacy of anticonvulsant Details Orlistat Fosphenytoin Sodium Reduced efficacy of anticonvulsant Details Orlistat Gabapentin Gabarone Reduced efficacy of anticonvulsant Details Orlistat Gabapentin Enacarbil Horizant Reduced efficacy of anticonvulsant Details Orlistat Ganaxolone Ztalmy Reduced efficacy of anticonvulsant Details Orlistat Gliclazide An increased risk of hypoglycemia Details Orlistat Glyburide DiaBeta® An increased risk of hypoglycemia Details Orlistat Indinavir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Insulin Afrezza An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.