Orlistat

144 interactions 77 cited references

Also sold as: Alli Alli® Xenical Xenical®

About Orlistat

Orlistat (prescription and nonprescription) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. Orlistat is also used after weight… Read the full Orlistat drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Nasal Spray Zonisamide Diazepam Nasal Spray Lacosamide Injection Insulin Glulisine (Rdna Origin) Injection Brivaracetam

139 Major 4 Moderate 1 Minor

All (144) Major (139) Moderate (4) Minor (1)

Major

Orlistat Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Orlistat Insulin Bovine An increased risk of hypoglycemia Details Orlistat Insulin Degludec Tresiba An increased risk of hypoglycemia Details Orlistat Insulin Detemir Levemir An increased risk of hypoglycemia Details Orlistat Insulin Glulisine Apidra An increased risk of hypoglycemia Details Orlistat Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Orlistat Lacosamide Motpoly Reduced efficacy of anticonvulsant Details Orlistat Lamotrigine Lamictal Reduced efficacy of anticonvulsant Details Orlistat Lepirudin An increased risk of bleeding Details Orlistat Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Orlistat Lopinavir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Lorazepam Ativan Reduced efficacy of anticonvulsant Details Orlistat Magnesium Sulfate Reduced efficacy of anticonvulsant Details Orlistat Midazolam Reduced efficacy of anticonvulsant Details Orlistat Midazolam Hydrochloride Reduced efficacy of anticonvulsant Details Orlistat Nadroparin An increased risk of bleeding Details Orlistat Nelfinavir Viracept Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Oxcarbazepine Oxtellar Reduced efficacy of anticonvulsant Details Orlistat Parnaparin An increased risk of bleeding Details Orlistat Pentobarbital Sodium Reduced efficacy of anticonvulsant Details Orlistat Perampanel FYCOMPA Reduced efficacy of anticonvulsant Details Orlistat Phenindione An increased risk of bleeding Details Orlistat Phenobarbital Fidoquel Reduced efficacy of anticonvulsant Details Orlistat Phenobarbital Sodium Reduced efficacy of anticonvulsant Details Orlistat Phenprocoumon An increased risk of bleeding Details Orlistat Phenytoin Dilantin Reduced efficacy of anticonvulsant Details Orlistat Phenytoin Sodium Reduced efficacy of anticonvulsant Details Orlistat Phenytoin Sodium, Extended Reduced efficacy of anticonvulsant Details Orlistat Piracetam Reduced efficacy of anticonvulsant Details Orlistat Pregabalin Bonqat Reduced efficacy of anticonvulsant Details Orlistat Primidone Mysoline Reduced efficacy of anticonvulsant Details Orlistat Protein C Ceprotin An increased risk of bleeding Details Orlistat Raltegravir Isentress Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Reviparin An increased risk of bleeding Details Orlistat Rilpivirine Edurant Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Ritonavir Norvir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Rivaroxaban Xarelto An increased risk of bleeding Details Orlistat Rufinamide Banzel Reduced efficacy of anticonvulsant Details Orlistat Saquinavir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Stavudine Zerit® Reduced efficacy of antiretrovirals, loss of virological control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.