Orlistat

144 interactions 77 cited references
Also sold as: Alli Alli® Xenical Xenical®
About Orlistat

Orlistat (prescription and nonprescription) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. Orlistat is also used after weight… Read the full Orlistat drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Nasal Spray Zonisamide Diazepam Nasal Spray Lacosamide Injection Insulin Glulisine (Rdna Origin) Injection Brivaracetam
139 Major 4 Moderate 1 Minor
All (144) Major (139) Moderate (4) Minor (1)

Major

Orlistat Stiripentol Diacomit Reduced efficacy of anticonvulsant Details Orlistat Sulodexide An increased risk of bleeding Details Orlistat Telaprevir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Tenofovir Disoproxil Fumarate Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Tiagabine Gabitril Reduced efficacy of anticonvulsant Details Orlistat Tiagabine Hydrochloride Reduced efficacy of anticonvulsant Details Orlistat Tinzaparin An increased risk of bleeding Details Orlistat Tipranavir Aptivus Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Tolazamide Tolinase® An increased risk of hypoglycemia Details Orlistat Tolbutamide Orinase® An increased risk of hypoglycemia Details Orlistat Topiramate Eprontia Reduced efficacy of anticonvulsant Details Orlistat Triheptanoin Orlistat, a pancreatic lipase inhibitor, may reduce absorption leading to insufficient supplementation Details Orlistat Valproate Sodium Reduced efficacy of anticonvulsant Details Orlistat Valproic Acid Depakene® Reduced efficacy of anticonvulsant Details Orlistat Venlafaxine An increase risk of adverse events Details Orlistat Vigabatrin Sabril Reduced efficacy of anticonvulsant Details Orlistat Warfarin Coumadin An increased risk of bleeding Details Orlistat Zidovudine Retrovir Reduced efficacy of antiretrovirals, loss of virological control Details Orlistat Zonisamide Zonegran Reduced efficacy of anticonvulsant Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.