Oxybutynin

21 interactions 3 explained in plain English
Also sold as: Ditropan Gelnique Oxytrol
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Hydromorphone Injection Morphine Injection Glucagon Injection / Solution Hydroxychloroquine
11 Major 10 Moderate
All (21) Major (11) Moderate (10)

Major

Oxybutynin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Oxybutynin Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Oxybutynin Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Oxybutynin Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Oxybutynin Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Oxybutynin Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Oxybutynin Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Oxybutynin Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxybutynin Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxybutynin Hydroxychloroquine Plaquenil An increased risk of seizures Details Oxybutynin Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

Moderate

Oxybutynin Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details Oxybutynin Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Oxybutynin Galantamine Razadyne Decreased efficacy of the cholinesterase inhibitor Details Oxybutynin Ketoconazole Topical Extina® Foam Increased oxybutynin plasma concentrations Details Oxybutynin Metoclopramide Injection Gimoti Decreased metoclopramide efficacy Details Oxybutynin Metoclopramide Nasal Spray Gimoti Decreased metoclopramide efficacy Details Oxybutynin Miconazole Buccal Oravig Increased oxybutynin exposure or plasma concentrations Details Oxybutynin Miconazole Topical Aloe Vesta Antifungal Increased oxybutynin exposure or plasma concentrations Details Oxybutynin Miconazole Vaginal Lagicam Increased oxybutynin exposure or plasma concentrations Details Oxybutynin Miconazole Aloe Vesta Antifungal Increased oxybutynin exposure or plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.