Oxypurinol

12 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Didanosine Azathioprine Capecitabine Captopril Enalapril Fluorouracil
1 Contraindicated 9 Major 2 Moderate
All (12) Contraindicated (1) Major (9) Moderate (2)

Contraindicated

Oxypurinol Didanosine Videx® Increased serum concentrations of didanosine Details

Major

Oxypurinol Azathioprine Azasan An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Oxypurinol Capecitabine Xeloda Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Oxypurinol Captopril Capoten® Hypersensitivity reactions (Stevens-Johnson syndrome, skin eruptions) Details Oxypurinol Enalapril Epaned Hypersensitivity reactions (Stevens-Johnson syndrome, skin eruptions, anaphylactic coronary spasm) Details Oxypurinol Fluorouracil Adrucil Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Oxypurinol Fluorouracil Injection Adrucil Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Oxypurinol Fluorouracil Topical Carac Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Oxypurinol Mercaptopurine Purinethol® An increased risk of myelosuppression, an increased risk of hepatotoxicity and an azaTHIOprine toxicity (nausea, vomiting, leukope... Details Oxypurinol Pegloticase Injection Krystexxa Increased risk of anaphylaxis and infusion reactions Details

Moderate

Oxypurinol Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Oxypurinol Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details

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