Drug Interaction Report

Ozanimod and Levodopa Oral Inhalation: Interaction Details

A pharmacist-reviewed analysis of the Ozanimod and Levodopa Oral Inhalation interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Ozanimod

No brand names on record
+

Levodopa Oral Inhalation

Inbrija Inbrija®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 86 documented Ozanimod interactions, 70 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased risk of levodopa adverse effects, including severe orthostatic hypotension

Interaction Deep Dive

Levodopa or carbidopa/levodopa may be administered with the recommended dose of an MAO-B inhibitor1345. However, coadministration of selegiline or rasagiline, MAO-B inhibitors, with carbidopa and carbidopa/levodopa may be associated with severe orthostatic hypotension that cannot be attributed to carbidopa/levodopa alone 1. An exacerbation of levodopa-associated side effects may occur in some patients taking selegiline, which may be alleviated by reducing the dose of levodopa/carbidopa by about 10% to 30% 6. Monitor patients taking carbidopa/levodopa and MAO-B inhibitors concurrently 2.

Why it happens (mechanism)

Increased DOPamine and norepinephrine levels

Common questions

Can I take Ozanimod and Levodopa Oral Inhalation together?

Increased risk of levodopa adverse effects, including severe orthostatic hypotension Always confirm with your pharmacist or prescriber before making any change.

How serious is the Ozanimod and Levodopa Oral Inhalation interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Ozanimod or Levodopa Oral Inhalation need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (6)

  1. Product Information: LODOSYN(R) oral tablets, carbidopa oral tablets. Valeant Pharmaceuticals North America LLC (per FDA), Bridgewater, NJ, 2014. DailyMed
  2. Product Information: CREXONT(TM)oral extended-release capsules, carbidopa, levodopa oral extended-release capsules. Amneal Specialty (per FDA), Bridgewater, NJ, 2024. DailyMed
  3. Product Information: SINEMET(R) oral tablets, carbidopa levodopa oral tablets. Merck Sharp & Dohme Corp. (per DailyMed), Whitehouse Station, NJ, 2013. DailyMed
  4. Product Information: SINEMET(R) CR oral sustained release tablets, carbidopa levodopa oral sustained release tablets. Merck Sharp & Dohme Corp. (per DailyMed), Whitehouse Station, NJ, 2013.
  5. Product Information: PARCOPA(R) oral disintegrating tablets, carbidopa levodopa oral disintegrating tablets. Azur Pharma, Inc. (per manufacturer), Philadelphia, PA, 2011. DailyMed
  6. Product Information: ELDEPRYL(R) oral capsules, selegiline HCl oral capsules. Dey Pharma, L.P. (per DailyMed), Napa, CA, 2011.
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Ozanimod

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Levodopa Oral Inhalation

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All Levodopa Oral Inhalation interactions (208) Levodopa Oral Inhalation drug information
Also serious with: Linezolid Methylene Blue Moclobemide Nialamide

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