Ozanimod

86 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Methyldopa Methylphenidate Transdermal Patch Morphine Injection Methylphenidate Maprotiline
8 Contraindicated 70 Major 8 Moderate
All (86) Contraindicated (8) Major (70) Moderate (8)

Contraindicated

Ozanimod Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serious adverse reactions and an increased risk of serotonin syndrome or opioid-related toxicity Details Ozanimod Sertraline Explained An increased risk of serotonin syndrome and an increased risk of serious adverse reactions Details Ozanimod Linezolid Injection Zyvox Altered ozanimod exposure and/or its metabolites Details Ozanimod Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Ozanimod Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Ozanimod Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Ozanimod Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Ozanimod Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details

Major

Ozanimod Amitriptyline Elavil Explained Increased risk of serious adverse reactions and additive effects on heart rate Details Ozanimod Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Ozanimod Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity, an increased risk of serious adverse reactions and additive ef... Details Ozanimod Amisulpride Injection Barhemsys Additive effects on heart rate Details Ozanimod Arsenic Trioxide Trisenox Additive effects on heart rate Details Ozanimod Aripiprazole Injection Abilify Additive effects on heart rate Details Ozanimod Arsenic Trioxide Injection Trisenox Additive effects on heart rate Details Ozanimod Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Ozanimod Asenapine Transdermal Patch Secuado Additive effects on heart rate Details Ozanimod Azithromycin AzaSite Additive effects on heart rate Details Ozanimod Alfuzosin UroXatral Additive effects on heart rate Details Ozanimod Anagrelide Agrylin Additive effects on heart rate Details Ozanimod Bedaquiline Sirturo Additive effects on heart rate Details Ozanimod Butorphanol Injection Butorphic Increased risk of serious adverse reactions Details Ozanimod Butorphanol Nasal Spray Stadol® NS Increased risk of serious adverse reactions Details Ozanimod Capmatinib Tabrecta Increased BCRP substrate exposure and an increased risk of adverse reactions Details Ozanimod Chloroquine Aralen® Additive effects on heart rate Details Ozanimod Dasatinib Phyrago Additive effects on heart rate Details Ozanimod Degarelix Injection Firmagon Additive effects on heart rate Details Ozanimod Deutetrabenazine Austedo Additive effects on heart rate Details Ozanimod Disopyramide Norpace Additive effects on heart rate Details Ozanimod Dofetilide Tikosyn Additive effects on heart rate Details Ozanimod Dolasetron Anzemet Additive effects on heart rate Details Ozanimod Dolasetron Injection Anzemet Additive effects on heart rate Details Ozanimod Encorafenib Braftovi Increased ozanimod exposure, an increased risk of ozanimod-related toxicities, additive effects on heart rate and an increased ris... Details Ozanimod Entrectinib Rozlytrek Additive effects on heart rate Details Ozanimod Eribulin Injection Halaven Additive effects on heart rate Details Ozanimod Famotidine Calmicid Additive effects on heart rate Details Ozanimod Famotidine Injection Calmicid Additive effects on heart rate Details Ozanimod Felbamate Felbatol Additive effects on heart rate Details Ozanimod Fentanyl Transdermal Patch Duragesic® Increased risk of serious adverse reactions and an increased risk of serotonin syndrome or opioid toxicity Details Ozanimod Flecainide Tambocor® Additive effects on heart rate Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.