Paliperidone

84 interactions 5 explained in plain English

Also sold as: Erzofri Invega

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Nasal Spray Metoclopramide Injection Ketoconazole Topical Oxaliplatin Injection Midazolam Nasal Spray Histrelin Implant

2 Contraindicated 81 Major 1 Moderate

All (84) Contraindicated (2) Major (81) Moderate (1)

Contraindicated

Paliperidone Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Paliperidone Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Paliperidone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Paliperidone Amitriptyline Elavil Explained An increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Sertraline Explained An increased risk of QT interval prolongation Details Paliperidone Buprenorphine Belbuca Explained An increased risk of CNS depression, an increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Paliperidone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Paliperidone Arsenic Trioxide Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Paliperidone Aripiprazole Injection Abilify An increased risk of CNS depression, an increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Arsenic Trioxide Injection Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Paliperidone Asenapine Transdermal Patch Secuado An increased risk of CNS depression, increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Paliperidone Alfuzosin UroXatral An increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Anagrelide Agrylin Increased risk of QT interval prolongation Details Paliperidone Bedaquiline Sirturo Increased risk of QT interval prolongation Details Paliperidone Butorphanol Injection Butorphic An increased risk of CNS depression Details Paliperidone Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Paliperidone Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Paliperidone Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Paliperidone Chloroquine Aralen® An increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Dasatinib Phyrago An increased risk of QT interval prolongation Details Paliperidone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Paliperidone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Paliperidone Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Paliperidone Diazepam Rectal Diastat An increased risk of CNS depression Details Paliperidone Diphenhydramine Injection Banophen An increased risk of CNS depression Details Paliperidone Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Paliperidone Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Paliperidone Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Paliperidone Dolasetron Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Dolasetron Injection Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Encorafenib Braftovi Increased risk of QT interval prolongation Details Paliperidone Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Paliperidone Eribulin Injection Halaven Increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Paliperidone Famotidine Calmicid Increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Famotidine Injection Calmicid Increased risk of QT interval prolongation and torsade de pointes Details Paliperidone Felbamate Felbatol Increased risk of QT interval prolongation and torsade de pointes Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.