Papaveretum

29 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Palonosetron Injection Buprenorphine Diazepam Nasal Spray Granisetron Injection Midazolam Nasal Spray
27 Major 2 Moderate
All (29) Major (27) Moderate (2)

Major

Papaveretum Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Papaveretum Sertraline Explained An increased risk of serotonin syndrome Details Papaveretum Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Papaveretum Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Papaveretum Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Papaveretum Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Papaveretum Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Papaveretum Clopidogrel Plavix Reduced efficacy of clopidogrel Details Papaveretum Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Papaveretum Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Papaveretum Esketamine Nasal Spray Spravato Increased risk of sedation Details Papaveretum Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Papaveretum Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Papaveretum Granisetron Injection Granisol Increased risk of serotonin syndrome Details Papaveretum Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Papaveretum Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Papaveretum Lacosamide Injection Motpoly An increased risk of CNS depression Details Papaveretum Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Papaveretum Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Papaveretum Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Papaveretum Metoclopramide Injection Gimoti Increased risk of CNS depression Details Papaveretum Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Papaveretum Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Papaveretum Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Papaveretum Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Papaveretum Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Papaveretum Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.