Penicillin G Procaine

16 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Demeclocycline Doxycycline Injection Eravacycline Injection Estradiol Estradiol Topical Estradiol Transdermal Patch
10 Major 6 Minor
All (16) Major (10) Minor (6)

Major

Penicillin G Procaine Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Penicillin G Procaine Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Penicillin G Procaine Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Penicillin G Procaine Estradiol Delestrogen Decreased contraceptive effectiveness Details Penicillin G Procaine Estradiol Topical Divigel Decreased contraceptive effectiveness Details Penicillin G Procaine Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Penicillin G Procaine Levonorgestrel After banger Decreased contraceptive effectiveness Details Penicillin G Procaine Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Penicillin G Procaine Minocycline Amzeeq Decreased antibacterial effectiveness Details Penicillin G Procaine Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Minor

Penicillin G Procaine Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Penicillin G Procaine Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Penicillin G Procaine Chloramphenicol Injection Chloromycetin® Injection Decreased antibacterial effectiveness Details Penicillin G Procaine Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Penicillin G Procaine Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Penicillin G Procaine Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.