Penicillin V

21 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Demeclocycline Levonorgestrel Intrauterine System Minocycline Estradiol Estradiol Topical Hydroxychloroquine
14 Major 1 Moderate 6 Minor
All (21) Major (14) Moderate (1) Minor (6)

Major

Penicillin V Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Penicillin V Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Penicillin V Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Penicillin V Estradiol Delestrogen Decreased contraceptive effectiveness Details Penicillin V Estradiol Topical Divigel Decreased contraceptive effectiveness Details Penicillin V Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Penicillin V Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Penicillin V Hydroxychloroquine Plaquenil An increased risk of seizures Details Penicillin V Levonorgestrel After banger Decreased contraceptive effectiveness Details Penicillin V Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Penicillin V Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Penicillin V Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Penicillin V Minocycline Amzeeq Decreased antibacterial effectiveness Details Penicillin V Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Moderate

Penicillin V Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

Minor

Penicillin V Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Penicillin V Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Penicillin V Chloramphenicol Injection Chloromycetin® Injection Decreased antibacterial effectiveness Details Penicillin V Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Penicillin V Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Penicillin V Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.