Pentosan Polysulfate Sodium

36 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ibuprofen Diclofenac Ophthalmic Etodolac Bromfenac Ophthalmic Enoxaparin Naproxen
33 Major 3 Moderate
All (36) Major (33) Moderate (3)

Major

Pentosan Polysulfate Sodium Apixaban Eliquis Explained An increased risk of bleeding Details Pentosan Polysulfate Sodium Aspirin Acuprin® An increased risk of bleeding Details Pentosan Polysulfate Sodium Aspirin Rectal Aspirin An increased risk of bleeding Details Pentosan Polysulfate Sodium Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Pentosan Polysulfate Sodium Dabigatran Pradaxa® An increased risk of bleeding Details Pentosan Polysulfate Sodium Dabigatran Etexilate An increased risk of bleeding Details Pentosan Polysulfate Sodium Dalteparin Injection Fragmin An increased risk of bleeding Details Pentosan Polysulfate Sodium Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Pentosan Polysulfate Sodium Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Pentosan Polysulfate Sodium Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Pentosan Polysulfate Sodium Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Pentosan Polysulfate Sodium Enoxaparin Lovenox An increased risk of bleeding Details Pentosan Polysulfate Sodium Enoxaparin Injection Lovenox An increased risk of bleeding Details Pentosan Polysulfate Sodium Etodolac Lodine An increased risk of bleeding Details Pentosan Polysulfate Sodium Fenoprofen Fenopron An increased risk of bleeding Details Pentosan Polysulfate Sodium Flurbiprofen Ansaid An increased risk of bleeding Details Pentosan Polysulfate Sodium Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Pentosan Polysulfate Sodium Fondaparinux Arixtra An increased risk of bleeding Details Pentosan Polysulfate Sodium Fondaparinux Injection Arixtra An increased risk of bleeding Details Pentosan Polysulfate Sodium Heparin An increased risk of bleeding Details Pentosan Polysulfate Sodium Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Pentosan Polysulfate Sodium Ibuprofen Addaprin An increased risk of bleeding Details Pentosan Polysulfate Sodium Ketoprofen Actron® An increased risk of bleeding Details Pentosan Polysulfate Sodium Ketorolac Acular An increased risk of bleeding Details Pentosan Polysulfate Sodium Ketorolac Injection Acular An increased risk of bleeding Details Pentosan Polysulfate Sodium Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Pentosan Polysulfate Sodium Ketorolac Ophthalmic Acular An increased risk of bleeding Details Pentosan Polysulfate Sodium Meclofenamate Meclodium® An increased risk of bleeding Details Pentosan Polysulfate Sodium Mefenamic Acid Ponstel® An increased risk of bleeding Details Pentosan Polysulfate Sodium Meloxicam Alloxate An increased risk of bleeding Details Pentosan Polysulfate Sodium Meloxicam Injection Alloxate An increased risk of bleeding Details Pentosan Polysulfate Sodium Nabumetone Relafen An increased risk of bleeding Details Pentosan Polysulfate Sodium Naproxen Aleve An increased risk of bleeding Details

Moderate

Pentosan Polysulfate Sodium Capsaicin Arthricare for Women Moisturizing Increased risk of bleeding Details Pentosan Polysulfate Sodium Capsaicin Topical Aspercreme Warming® Increased risk of bleeding Details Pentosan Polysulfate Sodium Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of bleeding Details

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