Perindopril and Cyclosporine Ophthalmic: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Perindopril
Cyclosporine Ophthalmic
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Acute renal dysfunction and an increased risk of hyperkalemia
Interaction Deep Dive
Use caution with coadministration of cycloSPORINE and perindopril, as both drugs may increase serum potassium and hyperkalemia may develop21. Monitor serum potassium frequently with concurrent use 2. Concomitant use may also increase the risk of renal impairment. Closely monitor renal function (especially serum creatinine). If significant renal impairment develops, consider dose reductions of 1 or both drugs or alternative therapies 1.
Why it happens (mechanism)
Decreased angiotensin II; additive hyperkalemia
Common questions
Can I take Perindopril and Cyclosporine Ophthalmic together?
Acute renal dysfunction and an increased risk of hyperkalemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Perindopril and Cyclosporine Ophthalmic interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Perindopril or Cyclosporine Ophthalmic need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: SANDIMMUNE(R) oral capsules, oral solution, intravenous injection, cyclosporine oral capsules, oral solution, intravenous injection. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
- Product Information: PRESTALIA(R) oral tablets, perindopril arginine amlodipine oral tablets. SYMPLMED LLC (per FDA), Cincinnati, OH, 2015. DailyMed
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