Phenprocoumon

97 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Bromfenac Ophthalmic Danazol Etodolac Nintedanib Oxandrolone

1 Contraindicated 69 Major 25 Moderate 2 Minor

All (97) Contraindicated (1) Major (69) Moderate (25) Minor (2)

Moderate

Phenprocoumon Amitriptyline Elavil Explained An increased risk of bleeding Details Phenprocoumon Azathioprine Azasan Reduced phenprocoumon efficacy Details Phenprocoumon Capsaicin Arthricare for Women Moisturizing Increased risk of bleeding Details Phenprocoumon Capsaicin Topical Aspercreme Warming® Increased risk of bleeding Details Phenprocoumon Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of bleeding Details Phenprocoumon Cholestyramine Resin Locholest® Decreased effects of phenprocoumon Details Phenprocoumon Dexamethasone Injection Decadron Increased risk of bleeding or diminished effects of phenprocoumon Details Phenprocoumon Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of bleeding or diminished effects of phenprocoumon Details Phenprocoumon Disulfiram Antabuse Increased risk of bleeding Details Phenprocoumon Fludrocortisone Acetate Florinef® Increased risk of bleeding or diminished effects of phenprocoumon Details Phenprocoumon Gemfibrozil Lopid An increased risk of bleeding Details Phenprocoumon Glimepiride Amaryl Excessive hypoglycemia Details Phenprocoumon Hydrocortisone Ala-Cort Increased risk of bleeding or diminished effects of phenprocoumon Details Phenprocoumon Hydrocortisone Injection A-Hydrocort® Increased risk of bleeding or diminished effects of phenprocoumon Details Phenprocoumon Ibritumomab Injection Zevalin® An increased risk of bleeding and hemorrhage Details Phenprocoumon Icosapent Ethyl Vascepa An increased risk of bleeding Details Phenprocoumon Lactulose Cholac® Elevated International Normalized Ratio serum values with potentiation of anticoagulation effects Details Phenprocoumon Lansoprazole Prevacid Elevations in International Normalized Ratio serum values and potentiation of anticoagulation effects Details Phenprocoumon Mercaptopurine Purinethol® Reduced phenprocoumon efficacy Details Phenprocoumon Methimazole Felanorm Decreased anticoagulant effectiveness Details Phenprocoumon Miconazole Buccal Oravig Increased risk of bleeding Details Phenprocoumon Miconazole Topical Aloe Vesta Antifungal Increased risk of bleeding Details Phenprocoumon Miconazole Vaginal Lagicam Increased risk of bleeding Details Phenprocoumon Miconazole Aloe Vesta Antifungal Increased risk of bleeding Details Phenprocoumon Mitapivat Aqvesme Reduced CYP2C9 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.