Phenytoin

237 interactions 11 explained in plain English
Also sold as: Dilantin Phenytek
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Phenytoin Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Phenytoin Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Phenytoin Calcifediol Rayaldee Altered serum levels of calcifediol Details Phenytoin Capecitabine Xeloda Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details Phenytoin Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details Phenytoin Carboplatin Kyxata Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Carboplatin Injection Kyxata Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Chloramphenicol Injection Chloromycetin® Injection Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Ciclesonide Nasal Spray Omnaris Reduced corticosteroid exposure Details Phenytoin Ciclesonide Oral Inhalation Alvesco Reduced corticosteroid exposure Details Phenytoin Cisplatin Injection Platinol-AQ® Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Clobetasol Byqlovi Reduced corticosteroid exposure Details Phenytoin Clobetasol Topical Clobex® Reduced corticosteroid exposure Details Phenytoin Cobimetinib Cotellic Decreased cobimetinib plasma concentrations Details Phenytoin Cyclophosphamide Cytoxan® Increased plasma concentrations of the active metabolite of cyclophosphamide and an increased risk of toxicity Details Phenytoin Cyclophosphamide Injection Cytoxan® Injection Increased plasma concentrations of the active metabolite of cyclophosphamide and an increased risk of toxicity Details Phenytoin Cyclosporine Injection Atopica Reduced cycloSPORINE exposure and potentially increased risk of organ rejection Details Phenytoin Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure and potentially increased risk of organ rejection Details Phenytoin Dabigatran Pradaxa® Reduced dabigatran exposure Details Phenytoin Dabigatran Etexilate Reduced dabigatran exposure Details Phenytoin Darolutamide Nubeqa Decreased darolutamide exposure Details Phenytoin Dasatinib Phyrago Reduced dasatinib exposure and reduced efficacy of dasatinib Details Phenytoin Deferasirox Exjade Decreased deferasirox concentrations Details Phenytoin Deflazacort Emflaza Decreased exposure to active metabolite of deflazacort Details Phenytoin Desonide Desowen Reduced corticosteroid exposure Details Phenytoin Desonide Topical Desonate® Reduced corticosteroid exposure Details Phenytoin Desoximetasone Topicort Reduced corticosteroid exposure Details Phenytoin Desoximetasone Topical Topicort Reduced corticosteroid exposure Details Phenytoin Dexamethasone Injection Decadron Reduced dexAMETHasone exposure Details Phenytoin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced dexAMETHasone exposure Details Phenytoin Diazepam Nasal Spray Valtoco Altered phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Diazepam Rectal Diastat Altered phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Diflorasone Topical Apexicon Reduced corticosteroid exposure Details Phenytoin Difluprednate Ophthalmic Durezol Reduced corticosteroid exposure Details Phenytoin Digoxin Cardoxin® Reduced digoxin exposure Details Phenytoin Disopyramide Norpace Reduced disopyramide exposure Details Phenytoin Disulfiram Antabuse Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Docetaxel Beizray Reduced docetaxel exposure Details Phenytoin Docetaxel Injection Beizray Reduced docetaxel exposure Details Phenytoin Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Reduced dolutegravir exposure and reduced efficacy of dolutegravir Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.