Phenytoin

Major

Phenytoin Dopamine Hypotension and/or cardiac arrest Details Phenytoin Doxorubicin Adriamycin Reduced DOXOrubicin exposure and reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Doxycycline Injection Acticlate Reduced doxycycline exposure Details Phenytoin Edoxaban Savaysa Reduced edoxaban exposure and an anticoagulant activity Details Phenytoin Elacestrant Orserdu Reduced elacestrant exposure and reduced efficacy of elacestrant Details Phenytoin Enasidenib Idhifa Increased CYP2C19 substrate exposure and an increased risk of CYP2C19 substrate-related adverse effects Details Phenytoin Encorafenib Braftovi Reduced encorafenib exposure and reduced efficacy of encorafenib Details Phenytoin Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Phenytoin Eravacycline Injection Xerava Reduced eravacycline concentrations and efficacy Details Phenytoin Erdafitinib Balversa Reduced erdafitinib exposure Details Phenytoin Erlotinib Tarceva Decreased erlotinib exposure and potential loss of efficacy Details Phenytoin Estradiol Delestrogen An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Estradiol Topical Divigel An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Estradiol Transdermal Patch Alora® An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Estramustine Emcyt An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Ethosuximide Zarontin Reduced ethosuximide exposure and an increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and risk of toxicity Details Phenytoin Everolimus Afinitor Reduced everolimus exposure and reduced efficacy of everolimus Details Phenytoin Exemestane Aromasin Reduced exemestane exposure Details Phenytoin Ezogabine Gabitril Decreased ezogabine plasma concentrations Details Phenytoin Famotidine Calmicid Increased phenytoin exposure and an increased risk of phenytoin toxicity Details Phenytoin Famotidine Injection Calmicid Increased phenytoin exposure and an increased risk of phenytoin toxicity Details Phenytoin Felbamate Felbatol An increased risk of phenytoin toxicity (ataxia, hyperreflexia, nystagmus, tremors), reduced felbamate exposure and reduced effica... Details Phenytoin Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Phenytoin Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Phenytoin Fludrocortisone Acetate Florinef® Reduced corticosteroid exposure Details Phenytoin Flunisolide Nasal Spray Nasalide® Reduced corticosteroid exposure Details Phenytoin Flunisolide Oral Inhalation AeroBid® Inhaler System Reduced corticosteroid exposure Details Phenytoin Fluocinolone Capex Reduced corticosteroid exposure Details Phenytoin Fluocinolone Topical Capex® Shampoo Reduced corticosteroid exposure Details Phenytoin Fluocinonide Vanos Reduced corticosteroid exposure Details Phenytoin Fluocinonide Topical Dermacin® Reduced corticosteroid exposure Details Phenytoin Fluorouracil Adrucil Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details Phenytoin Fluorouracil Injection Adrucil Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details Phenytoin Fluorouracil Topical Carac Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details Phenytoin Flurandrenolide Topical Cordran Reduced corticosteroid exposure Details Phenytoin Fluvastatin Lescol Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, increased risk of phenytoin or fosphenytoin toxicity and redu... Details Phenytoin Folic Acid Folacin Reduced folic acid exposure and reduce phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Fostamatinib Tavalisse Reduced exposure to the active metabolite Details Phenytoin Furosemide Injection Disal Reduced furosemide exposure Details Phenytoin Futibatinib Lytgobi Reduced futibatinib exposure and reduced efficacy Details