Phenytoin

Major

Phenytoin Gefitinib Iressa Decreased exposure of gefitinib Details Phenytoin Gilteritinib Xospata Reduced gilteritinib exposure Details Phenytoin Glasdegib Daurismo Decreased glasdegib exposure Details Phenytoin Halcinonide Topical Halog Reduced corticosteroid exposure Details Phenytoin Halobetasol Topical Duobrii (as a combination product containing Halobetasol, Tazarotene) Reduced corticosteroid exposure Details Phenytoin Hydrocortisone Ala-Cort Reduced corticosteroid exposure Details Phenytoin Hydrocortisone Injection A-Hydrocort® Reduced corticosteroid exposure Details Phenytoin Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Phenytoin Ibrexafungerp Brexafemme Decreased ibrexafungerp plasma concentrations Details Phenytoin Ibrutinib Imbruvica Decreased ibrutinib exposure Details Phenytoin Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Phenytoin Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Phenytoin Irinotecan Camptosar Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Phenytoin Irinotecan Injection Camptosar Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Phenytoin Irinotecan Lipid Complex Injection Onivyde® Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Phenytoin Istradefylline Nourianz Decreased istradefylline exposure Details Phenytoin Ivabradine Corlanor Decreased exposure of ivabradine Details Phenytoin Ixabepilone Injection IXEMPRA Decreased ixabepilone exposure and efficacy Details Phenytoin Ixazomib Ninlaro Decreased ixazomib exposure Details Phenytoin Ketoconazole Topical Extina® Foam Increased phenytoin exposure, reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Phenytoin Lacosamide Injection Motpoly Reduced lacosamide exposure Details Phenytoin Lefamulin Xenleta Reduced lefamulin exposure and reduced efficacy of lefamulin Details Phenytoin Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Phenytoin Letermovir Injection Prevymis Reduced phenytoin exposure, reduced letermovir exposure and reduced efficacy of letermovir Details Phenytoin Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Phenytoin Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Phenytoin Linagliptin Tradjenta Reduced linagliptin exposure Details Phenytoin Loteprednol Etabonate Alrex Reduced corticosteroid exposure Details Phenytoin Loteprednol Ophthalmic Alrex Reduced corticosteroid exposure Details Phenytoin Lumateperone Caplyta Reduced lumateperone exposure Details Phenytoin Lurbinectedin Injection Zepzelca Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Phenytoin Macitentan Opsumit Reduced macitentan exposure Details Phenytoin Maraviroc Selzentry Reduced maraviroc exposure Details Phenytoin Medroxyprogesterone Amen® Reduced medroxyPROGESTERone exposure Details Phenytoin Medroxyprogesterone Injection Depo-Provera Reduced medroxyPROGESTERone exposure Details Phenytoin Mefloquine Lariam® Reduced phenytoin exposure resulting in loss of seizure control Details Phenytoin Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Phenytoin Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Phenytoin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Phenytoin Mesalamine Apriso Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity Details