Phenytoin

Major

Phenytoin Mesalamine Rectal Canasa Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity Details Phenytoin Methotrexate Jylamvo Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure, reduced efficacy of phenytoin/fosphenytoin, an increased methot... Details Phenytoin Methotrexate Injection Abitrexate® Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure, reduced efficacy of phenytoin/fosphenytoin, an increased methot... Details Phenytoin Methsuximide Celontin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Methylergonovine Methergine Reduced methylergonovine exposure and reduced efficacy of methylergonovine Details Phenytoin Methylphenidate Adhansia XR® Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Methylphenidate Transdermal Patch Daytrana Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Phenytoin Metronidazole Flagyl An increased risk of phenytoin toxicity or reduced metroNIDAZOLE exposure Details Phenytoin Metronidazole Injection Flagyl An increased risk of phenytoin toxicity or reduced metroNIDAZOLE exposure Details Phenytoin Metronidazole Topical MetroCream® An increased risk of phenytoin toxicity or reduced metroNIDAZOLE exposure Details Phenytoin Metronidazole Vaginal MetroGel® Vaginal An increased risk of phenytoin toxicity or reduced metroNIDAZOLE exposure Details Phenytoin Mexiletine Mexitil® Reduced mexiletine exposure Details Phenytoin Miconazole Buccal Oravig Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Miconazole Topical Aloe Vesta Antifungal Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Miconazole Vaginal Lagicam Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Miconazole Aloe Vesta Antifungal Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Phenytoin Midostaurin Rydapt Decreased midostaurin exposure Details Phenytoin Mitapivat Aqvesme Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure, reduced mitapivat exposure and reduced efficacy of mitapivat Details Phenytoin Mometasone Asmanex Reduced corticosteroid exposure Details Phenytoin Mometasone Nasal Spray Nasonex Reduced corticosteroid exposure Details Phenytoin Mometasone Oral Inhalation Asmanex Reduced corticosteroid exposure Details Phenytoin Mometasone Topical Elocon® Reduced corticosteroid exposure Details Phenytoin Naloxegol Movantik Reduced naloxegol exposure and reduced efficacy of naloxegol Details Phenytoin Neratinib Nerlynx Decreased exposure of neratinib and active metabolites and risk of reduced efficacy Details Phenytoin Nimodipine Nimotop Reduced niMODipine exposure and reduced efficacy niMODipine efficacy Details Phenytoin Nintedanib Ofev Reduced nintedanib exposure Details Phenytoin Nisoldipine Sular Reduced nisoldipine exposure Details Phenytoin Nizatidine Axid® Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased rick of phenytoin or fosphenytoin toxicity Details Phenytoin Olaparib Lynparza Decreased olaparib exposure and efficacy Details Phenytoin Olutasidenib Rezlidhia Reduced olutasidenib exposure Details Phenytoin Orlistat Alli Reduced efficacy of anticonvulsant Details