Piperacillin

27 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Heparin Injection Edoxaban Dabigatran Methotrexate Enoxaparin Demeclocycline
22 Major 5 Minor
All (27) Major (22) Minor (5)

Major

Piperacillin Apixaban Eliquis Explained An increased risk of bleeding Details Piperacillin Betrixaban Bevyxxa® An increased risk of bleeding Details Piperacillin Dabigatran Pradaxa® An increased risk of bleeding Details Piperacillin Dabigatran Etexilate An increased risk of bleeding Details Piperacillin Dalteparin Injection Fragmin An increased risk of bleeding Details Piperacillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Piperacillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Piperacillin Edoxaban Savaysa An increased risk of bleeding Details Piperacillin Enoxaparin Lovenox An increased risk of bleeding Details Piperacillin Enoxaparin Injection Lovenox An increased risk of bleeding Details Piperacillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Piperacillin Fondaparinux Arixtra An increased risk of bleeding Details Piperacillin Fondaparinux Injection Arixtra An increased risk of bleeding Details Piperacillin Heparin An increased risk of bleeding Details Piperacillin Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Piperacillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Piperacillin Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Piperacillin Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Piperacillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Piperacillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Piperacillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Piperacillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.