Pirfenidone

Name: Pirfenidone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

4 interactions 1 explained in plain English

Also sold as: Esbriet Esbriet®

About Pirfenidone

Pirfenidone is used for the treatment of idiopathic pulmonary fibrosis (scarring of the lungs with an unknown cause). Pirfenidone is in a class of medications called pyridones. It works by blocking the action of a certain natural substance in the body that is involved in causing fibrosis. Read the full Pirfenidone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Capmatinib Interferon Alfa-2B Injection Mexiletine

4 Major

All (4) Major (4)

Major

Pirfenidone Abametapir Explained Increased exposure of CYP1A2 substrates Details Pirfenidone Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Pirfenidone Interferon Alfa-2B Injection Intron A® Increased pirfenidone exposure Details Pirfenidone Mexiletine Mexitil® Increased pirfenidone exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.