Pitolisant

97 interactions 6 explained in plain English

Also sold as: Wakix Wakix®

About Pitolisant

Pitolisant is used to treat excessive daytime sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) and to treat cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) in adults with narcolepsy. Pitolisant is in a class of medications called H3 blockers. I… Read the full Pitolisant drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Oxaliplatin Injection Amitriptyline Felbamate Nifedipine Alfuzosin

1 Contraindicated 94 Major 2 Moderate

All (97) Contraindicated (1) Major (94) Moderate (2)

Major

Pitolisant Abametapir Explained Increased exposure of CYP3A4 substrate Details Pitolisant Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Pitolisant Sertraline Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Pitolisant Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Pitolisant Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Pitolisant Alcaftadine Ophthalmic Lastacaft Reduced efficacy of pitolisant Details Pitolisant Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Pitolisant Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Pitolisant Aripiprazole Injection Abilify Increased risk of QT interval prolongation Details Pitolisant Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Pitolisant Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Pitolisant Atogepant Qulipta Reduced atogepant exposure Details Pitolisant Azithromycin AzaSite Increased risk of QT interval prolongation Details Pitolisant Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Pitolisant Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Pitolisant Alfuzosin UroXatral Increased risk of QT interval prolongation Details Pitolisant Amlodipine Amvaz® Reduced amLODIPine exposure Details Pitolisant Anagrelide Agrylin Increased risk of QT interval prolongation Details Pitolisant Azelastine Nasal Spray Astelin® Nasal Spray Reduced efficacy of pitolisant Details Pitolisant Azelastine Ophthalmic Optivar® Reduced efficacy of pitolisant Details Pitolisant Bedaquiline Sirturo Increased risk of QT interval prolongation Details Pitolisant Bepotastine Ophthalmic Bepreve Reduced efficacy of pitolisant Details Pitolisant Cetirizine Injection Aller-Tec Reduced efficacy of pitolisant Details Pitolisant Cetirizine Ophthalmic Zerviate Reduced efficacy of pitolisant Details Pitolisant Chloroquine Aralen® Increased risk of QT interval prolongation Details Pitolisant Dacomitinib Vizimpro Increased pitolisant exposure Details Pitolisant Dasatinib Phyrago Increased risk of QT interval prolongation Details Pitolisant Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Pitolisant Desloratadine Clarinex Reduced efficacy of pitolisant Details Pitolisant Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Pitolisant Diphenhydramine Injection Banophen Reduced efficacy of pitolisant Details Pitolisant Diphenhydramine Topical Afterbite with Antihistamine Reduced efficacy of pitolisant Details Pitolisant Disopyramide Norpace Increased risk of QT interval prolongation Details Pitolisant Dofetilide Tikosyn Increased risk of QT interval prolongation Details Pitolisant Dolasetron Anzemet Increased risk of QT interval prolongation Details Pitolisant Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Pitolisant Encorafenib Braftovi Reduced pitolisant exposure, an increased risk of QT interval prolongation and an increased risk of cardiac arrhythmias Details Pitolisant Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Pitolisant Epinastine Ophthalmic Elestat® Reduced efficacy of pitolisant Details Pitolisant Eribulin Injection Halaven Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.