Pitolisant

97 interactions 6 explained in plain English
Also sold as: Wakix Wakix®
About Pitolisant

Pitolisant is used to treat excessive daytime sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) and to treat cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) in adults with narcolepsy. Pitolisant is in a class of medications called H3 blockers. I… Read the full Pitolisant drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Oxaliplatin Injection Amitriptyline Felbamate Nifedipine Alfuzosin
1 Contraindicated 94 Major 2 Moderate
All (97) Contraindicated (1) Major (94) Moderate (2)

Major

Pitolisant Estradiol Delestrogen Reduced efficacy of hormonal contraceptives Details Pitolisant Estradiol Topical Divigel Reduced efficacy of hormonal contraceptives Details Pitolisant Estradiol Transdermal Patch Alora® Reduced efficacy of hormonal contraceptives Details Pitolisant Famotidine Calmicid Increased risk of QT interval prolongation Details Pitolisant Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Pitolisant Felbamate Felbatol Increased risk of QT interval prolongation Details Pitolisant Fexofenadine Allegra Reduced efficacy of pitolisant Details Pitolisant Flecainide Tambocor® Increased risk of QT interval prolongation Details Pitolisant Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Pitolisant Fostemsavir Rukobia Increased risk of torsade de pointes Details Pitolisant Galantamine Razadyne Increased risk of QT interval prolongation Details Pitolisant Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details Pitolisant Gemifloxacin Factive Increased risk of QT interval prolongation Details Pitolisant Glasdegib Daurismo Increased risk of QT interval prolongation Details Pitolisant Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Pitolisant Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Pitolisant Granisetron Injection Granisol Increased risk of QT interval prolongation Details Pitolisant Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Pitolisant Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Pitolisant Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Pitolisant Ivabradine Corlanor Increased risk of QT interval prolongation Details Pitolisant Ketotifen Alaway Reduced efficacy of pitolisant Details Pitolisant Ketotifen Ophthalmic Alaway Reduced efficacy of pitolisant Details Pitolisant Lefamulin Xenleta Increased risk of QT interval prolongation Details Pitolisant Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Pitolisant Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Pitolisant Levofloxacin Levaquin Increased risk of QT interval prolongation Details Pitolisant Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Pitolisant Levonorgestrel After banger Reduced efficacy of hormonal contraceptives Details Pitolisant Levonorgestrel Intrauterine System Kyleena Reduced efficacy of hormonal contraceptives Details Pitolisant Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Pitolisant Loratadine Agistam® Reduced efficacy of pitolisant Details Pitolisant Lumateperone Caplyta Reduced lumateperone exposure Details Pitolisant Medroxyprogesterone Amen® Reduced efficacy of hormonal contraceptives Details Pitolisant Medroxyprogesterone Injection Depo-Provera Reduced efficacy of hormonal contraceptives Details Pitolisant Mefloquine Lariam® Increased risk of QT interval prolongation Details Pitolisant Metronidazole Flagyl Increased risk of QT interval prolongation Details Pitolisant Metronidazole Injection Flagyl Increased risk of QT interval prolongation Details Pitolisant Metronidazole Topical MetroCream® Increased risk of QT interval prolongation Details Pitolisant Metronidazole Vaginal MetroGel® Vaginal Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.