Polythiazide
64 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Miglitol
Fentanyl Transdermal Patch
Nateglinide
Linagliptin
Insulin Glulisine (Rdna Origin) Injection
Etodolac
Major
Polythiazide Liraglutide Injection Saxenda An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Lithium Carbonate Lithobid Lithium toxicity Details Polythiazide Lixisenatide Injection Adlyxin® An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Polythiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.