Polythiazide

64 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Polythiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Polythiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Polythiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Polythiazide Acarbose Prandase® Explained An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Polythiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Polythiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Alogliptin Nesina An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Canagliflozin Invokana An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Dapagliflozin Farxiga An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Polythiazide Dulaglutide Injection Trulicity An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Exenatide Injection Bydureon An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Polythiazide Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Polythiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Glimepiride Amaryl An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Glipizide Glucotrol An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Polythiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Polythiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hyperglycemia and an increased insulin requirement Details Polythiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Polythiazide Linagliptin Tradjenta An increased risk of hyperglycemia and an increased insulin requirement Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.