Ponesimod

81 interactions 5 explained in plain English

Also sold as: Ponvory Ponvory®

About Ponesimod

Ponesimod is used to prevent episodes of symptoms and slow the worsening of disability in adults who have relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bla… Read the full Ponesimod drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Nifedipine Moxifloxacin Alfuzosin Felbamate Penbutolol

81 Major

All (81) Major (81)

Major

Ponesimod Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Ponesimod Sertraline Explained An increased risk of QT interval prolongation Details Ponesimod Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Ponesimod Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Ponesimod Amisulpride Injection Barhemsys An increased risk of QT interval prolongation Details Ponesimod Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Ponesimod Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Ponesimod Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Ponesimod Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Ponesimod Atenolol Tenormin Explained An increased risk of severe bradycardia and heart block Details Ponesimod Azithromycin AzaSite An increased risk of QT interval prolongation Details Ponesimod Acebutolol Sectral® An increased risk of severe bradycardia and heart block Details Ponesimod Alfuzosin UroXatral An increased risk of QT interval prolongation Details Ponesimod Amlodipine Amvaz® An increased risk of bradycardia and heart block Details Ponesimod Anagrelide Agrylin An increased risk of QT interval prolongation Details Ponesimod Bedaquiline Sirturo An increased risk of QT interval prolongation Details Ponesimod Betaxolol Betoptic S An increased risk of severe bradycardia and heart block Details Ponesimod Betaxolol Ophthalmic Betoptic® An increased risk of severe bradycardia and heart block Details Ponesimod Bisoprolol Zebeta® An increased risk of severe bradycardia and heart block Details Ponesimod Chloroquine Aralen® An increased risk of QT interval prolongation Details Ponesimod Dasatinib Phyrago An increased risk of QT interval prolongation Details Ponesimod Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Ponesimod Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Ponesimod Digoxin Cardoxin® An increased risk of severe bradycardia and heart block Details Ponesimod Disopyramide Norpace Increased risk of bradycardia, an increased risk of QT prolongation and torsades de pointes Details Ponesimod Dofetilide Tikosyn Increased risk of bradycardia, an increased risk of QT interval prolongation and torsades de pointes Details Ponesimod Dolasetron Anzemet An increased risk of QT interval prolongation Details Ponesimod Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Ponesimod Encorafenib Braftovi An increased risk of QT interval prolongation Details Ponesimod Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Ponesimod Eribulin Injection Halaven An increased risk of QT interval prolongation Details Ponesimod Esmolol Brevibloc An increased risk of severe bradycardia and heart block Details Ponesimod Famotidine Calmicid An increased risk of QT interval prolongation Details Ponesimod Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Ponesimod Felbamate Felbatol An increased risk of QT interval prolongation Details Ponesimod Felodipine Plendil® An increased risk of bradycardia and heart block Details Ponesimod Flecainide Tambocor® An increased risk of QT interval prolongation Details Ponesimod Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Ponesimod Galantamine Razadyne An increased risk of QT interval prolongation Details Ponesimod Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.