Prednisolone

53 interactions 1 explained in plain English

Also sold as: Flo-Pred® MILLIPRED Orapred Orapred® Pediapred Pediapred® Pred Forte Pred Mild Prednistab Veripred

About Prednisolone

Prednisolone is a corticosteroid used to treat low corticosteroid levels, inflammation, immune system disorders, and prevent transplant rejection. Read the full Prednisolone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Moxifloxacin Ofloxacin Otic Estradiol Topical Asparaginase Erwinia Chrysanthemi Injection Etodolac

1 Contraindicated 41 Major 11 Moderate

All (53) Contraindicated (1) Major (41) Moderate (11)

Contraindicated

Prednisolone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details

Major

Prednisolone Aldesleukin Proleukin Reduced antitumor effectiveness Details Prednisolone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Prednisolone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Prednisolone Asparaginase Erwinia Chrysanthemi Injection Erwinaze An increased risk of bleeding Details Prednisolone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Prednisolone Bromfenac Ophthalmic Bromday® Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Estradiol Delestrogen Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Prednisolone Estradiol Topical Divigel Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Prednisolone Estradiol Transdermal Patch Alora® Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Prednisolone Etodolac Lodine Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Fenoprofen Fenopron Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Flurbiprofen Ansaid Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Flurbiprofen Ophthalmic Ocufen Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Prednisolone Gemifloxacin Factive An increased risk of tendon rupture Details Prednisolone Ibuprofen Addaprin Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Ketoprofen Actron® Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Ketorolac Acular Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Ketorolac Injection Acular Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Ketorolac Nasal Spray Sprix Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Ketorolac Ophthalmic Acular Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Levofloxacin Levaquin An increased risk of tendon rupture Details Prednisolone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Prednisolone Levonorgestrel After banger Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Prednisolone Levonorgestrel Intrauterine System Kyleena Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Prednisolone Meclofenamate Meclodium® Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Mefenamic Acid Ponstel® Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Meloxicam Alloxate Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Meloxicam Injection Alloxate Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Moxifloxacin Avelox An increased risk of tendon rupture Details Prednisolone Moxifloxacin Injection Avelox An increased risk of tendon rupture Details Prednisolone Moxifloxacin Ophthalmic Moxeza® An increased risk of tendon rupture Details Prednisolone Nabumetone Relafen Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Naproxen Aleve Increased risk of gastrointestinal ulcer or bleeding Details Prednisolone Ofloxacin Floxin® An increased risk of tendon rupture Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.