Prednisolone

53 interactions 1 explained in plain English
Also sold as: Flo-Pred® MILLIPRED Orapred Orapred® Pediapred Pediapred® Pred Forte Pred Mild Prednistab Veripred
About Prednisolone

Prednisolone is a corticosteroid used to treat low corticosteroid levels, inflammation, immune system disorders, and prevent transplant rejection. Read the full Prednisolone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Moxifloxacin Ofloxacin Otic Estradiol Topical Asparaginase Erwinia Chrysanthemi Injection Etodolac
1 Contraindicated 41 Major 11 Moderate
All (53) Contraindicated (1) Major (41) Moderate (11)

Major

Prednisolone Ofloxacin Ophthalmic Ocuflox An increased risk of tendon rupture Details Prednisolone Ofloxacin Otic Floxin® Otic An increased risk of tendon rupture Details

Moderate

Prednisolone Apixaban Eliquis Explained Increased risk of gastrointestinal bleeding Details Prednisolone Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Prednisolone Cyclosporine Injection Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) and symptoms of steroid excess Details Prednisolone Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) and symptoms of steroid excess Details Prednisolone Dabigatran Pradaxa® Increased risk of gastrointestinal bleeding Details Prednisolone Dabigatran Etexilate Increased risk of gastrointestinal bleeding Details Prednisolone Edoxaban Savaysa Increased risk of gastrointestinal bleeding Details Prednisolone Ketoconazole Topical Extina® Foam An increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electrolyte disturbances, hypertension, hy... Details Prednisolone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Prednisolone Neostigmine Methylsulfate Bloxiverz Decreased neostigmine effectiveness Details Prednisolone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.