Pretomanid

Name: Pretomanid Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 1 explained in plain English

About Pretomanid

Pretomanid is used along with bedaquiline (Sirturo) and linezolid (Zyvox) to treat multi-drug resistant tuberculosis (MDR-TB; a serious infection that affects the lungs that cannot be treated with other medications) in adults. Pretomanid is in a class of medications called antimycobacterials. It works by killing the ba… Read the full Pretomanid drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Atogepant Cariprazine Amlodipine Lumateperone Nafcillin Injection Nifedipine

6 Major 2 Moderate

All (8) Major (6) Moderate (2)

Major

Pretomanid Atogepant Qulipta Reduced atogepant exposure Details Pretomanid Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Pretomanid Amlodipine Amvaz® Reduced amLODIPine exposure Details Pretomanid Lumateperone Caplyta Reduced lumateperone exposure Details Pretomanid Nafcillin Injection Unipen® Injection Decreased plasma levels of pretomanid Details Pretomanid Nifedipine Adalat® Reduced NIFEdipine exposure Details

Moderate

Pretomanid Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Pretomanid Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.