Prochlorperazine
83 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Nasal Spray
Dofetilide
Metoclopramide Injection
Alfuzosin
Oxaliplatin Injection
Butorphanol Nasal Spray
Contraindicated
Prochlorperazine Dofetilide Tikosyn Increased dofetilide exposure, an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details Prochlorperazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Prochlorperazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Prochlorperazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Prochlorperazine Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Sertraline Explained An increased risk of QT interval prolongation Details Prochlorperazine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Prochlorperazine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Prochlorperazine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Prochlorperazine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Prochlorperazine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Prochlorperazine Azithromycin AzaSite An increased risk of QT interval prolongation Details Prochlorperazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Prochlorperazine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Prochlorperazine Anagrelide Agrylin Increased risk of QT interval prolongation Details Prochlorperazine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Prochlorperazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Prochlorperazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Prochlorperazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Prochlorperazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Prochlorperazine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Dasatinib Phyrago An increased risk of QT interval prolongation Details Prochlorperazine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Prochlorperazine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Prochlorperazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Prochlorperazine Diazepam Rectal Diastat Increased risk of CNS depression Details Prochlorperazine Disopyramide Norpace An increased risk of QT interval prolongation Details Prochlorperazine Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Encorafenib Braftovi Increased risk of QT interval prolongation Details Prochlorperazine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Prochlorperazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Prochlorperazine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Prochlorperazine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Fostemsavir Rukobia Increased risk of torsade de pointes Details Prochlorperazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Prochlorperazine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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