Propranolol

76 interactions 5 explained in plain English

Also sold as: Hemangeol Inderal InnoPran

Read the full Propranolol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Olodaterol Oral Inhalation Capmatinib Mefloquine Dihydroergotamine Injection Lacosamide Injection

11 Major 65 Moderate

All (76) Major (11) Moderate (65)

Moderate

Propranolol Omeprazole Gastrobim Explained Increased propranolol exposure Details Propranolol Sertraline Explained Increased propranolol exposure Details Propranolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Propranolol Aspirin Acuprin® Reduced antihypertensive effect Details Propranolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Propranolol Abiraterone Abirtega Increased propranolol exposure Details Propranolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Propranolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Propranolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Cholestyramine Resin Locholest® Decreased propranolol exposure Details Propranolol Colestipol Colestid Decreased propranolol effectiveness Details Propranolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Propranolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Propranolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Propranolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Propranolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Propranolol Dobutamine Reduced sensitivity to DOBUTamine stress echocardiography Details Propranolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Propranolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Esomeprazole Nexium Increased propranolol exposure Details Propranolol Esomeprazole Injection Nexium Increased propranolol exposure Details Propranolol Etodolac Lodine Reduced antihypertensive effect Details Propranolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Fenoprofen Fenopron Reduced antihypertensive effect Details Propranolol Flecainide Tambocor® Bradycardia, decreased cardiac output Details Propranolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Propranolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Propranolol Furosemide Injection Disal Hypotension, bradycardia Details Propranolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Propranolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Propranolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Propranolol Ibuprofen Addaprin Reduced antihypertensive effect Details Propranolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.