Propranolol

76 interactions 5 explained in plain English
Also sold as: Hemangeol Inderal InnoPran

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Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Olodaterol Oral Inhalation Capmatinib Mefloquine Dihydroergotamine Injection Lacosamide Injection
11 Major 65 Moderate
All (76) Major (11) Moderate (65)

Moderate

Propranolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Interferon Alfa-2B Injection Intron A® Increased propranolol exposure Details Propranolol Ketoprofen Actron® Reduced antihypertensive effect Details Propranolol Ketorolac Acular Reduced antihypertensive effect Details Propranolol Ketorolac Injection Acular Reduced antihypertensive effect Details Propranolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Propranolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Propranolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Meclofenamate Meclodium® Reduced antihypertensive effect Details Propranolol Mefenamic Acid Ponstel® Reduced antihypertensive effect Details Propranolol Meloxicam Alloxate Reduced antihypertensive effect Details Propranolol Meloxicam Injection Alloxate Reduced antihypertensive effect Details Propranolol Metformin Fortamet® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Methimazole Felanorm Altered metabolism of the beta-adrenergic blocker Details Propranolol Mexiletine Mexitil® Increased propranolol exposure Details Propranolol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Nabumetone Relafen Reduced antihypertensive effect Details Propranolol Naproxen Aleve Reduced antihypertensive effect Details Propranolol Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Propranolol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details Propranolol Obeticholic Acid Ocaliva Increased propranolol exposure Details Propranolol Peginterferon Alfa-2A Injection Pegasys Increased propranolol exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.