Propyphenazone

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Injection Ketorolac Nasal Spray Ketorolac Pemetrexed Injection Cyclosporine Ophthalmic
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Propyphenazone Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Propyphenazone Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Propyphenazone Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Propyphenazone Iloprost Aurlumyn An increased risk of bleeding Details Propyphenazone Ketoprofen Actron® Increased risk of bleeding Details Propyphenazone Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Propyphenazone Meclofenamate Meclodium® Increased risk of bleeding Details Propyphenazone Mefenamic Acid Ponstel® Increased risk of bleeding Details Propyphenazone Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Propyphenazone Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Propyphenazone Melphalan Alkeran An increased risk of bleeding Details Propyphenazone Melphalan Injection Alkeran An increased risk of bleeding Details Propyphenazone Mesalamine Apriso Increased risk of bleeding Details Propyphenazone Mesalamine Rectal Canasa Increased risk of bleeding Details Propyphenazone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Propyphenazone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Propyphenazone Nabumetone Relafen Increased risk of bleeding Details Propyphenazone Naproxen Aleve Increased risk of bleeding Details Propyphenazone Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.