Pseudoephedrine

Name: Pseudoephedrine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

6 interactions

Also sold as: Afrinol® Allegra-D® (as a combination product containing Fexofenadine, Pseudoephedrine) Cenafed® Children's Sudafed Nasal Decongestant® Congestaclear® Contac Cold Efidac® Genaphed Myfedrine® Nexafed Pseudocot® Q-Fed Ridafed® Silfedrine® Sudafed Sudafed 12/24 Hour® Sudafed Congestion® Sudodrin® Sudogest SudoGest® Sudrine® Superfed® Suphedrin® Wal-Phed Zephrex-D

About Pseudoephedrine

Pseudoephedrine is a nasal decongestant used to relieve nasal and sinus congestion from colds, allergies, and hay fever. Read the full Pseudoephedrine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Injection Dihydroergotamine Nasal Spray Linezolid Injection Fentanyl Transdermal Patch Methyldopa Olodaterol Oral Inhalation

3 Contraindicated 3 Major

All (6) Contraindicated (3) Major (3)

Contraindicated

Pseudoephedrine Dihydroergotamine Injection DHE-45® Injection Extreme elevation of blood pressure Details Pseudoephedrine Dihydroergotamine Nasal Spray Migranal Extreme elevation of blood pressure Details Pseudoephedrine Linezolid Injection Zyvox Hypertensive crisis (headache, hyperpyrexia, hypertension) Details

Major

Pseudoephedrine Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect Details Pseudoephedrine Methyldopa Aldomet® Loss of blood pressure control and possibly hypertensive urgency Details Pseudoephedrine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.