Quinine

79 interactions 7 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lefamulin Ketoconazole Topical Colchicine Goserelin Implant Oxaliplatin Injection Alfuzosin
3 Contraindicated 70 Major 4 Moderate 2 Minor
All (79) Contraindicated (3) Major (70) Moderate (4) Minor (2)

Major

Quinine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Quinine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Quinine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Quinine Ivabradine Corlanor Increased risk of QT prolongation Details Quinine Lacosamide Injection Motpoly An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Quinine Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Quinine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Quinine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Quinine Levofloxacin Levaquin Increased risk of QT interval prolongation Details Quinine Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Quinine Loperamide Diamode Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Quinine Mefloquine Lariam® Increased mefloquine exposure and an increased risk of seizures, QT-interval prolongation, and torsade de pointes Details Quinine Metronidazole Flagyl An increased risk of QT interval prolongation Details Quinine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Quinine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Quinine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Quinine Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Quinine Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Quinine Moxifloxacin Avelox Increased risk of QT interval prolongation Details Quinine Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Quinine Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Quinine Nebivolol Bystolic Increased exposure to nebivolol Details Quinine Nevirapine Viramune Decreased quinine efficacy Details Quinine Octreotide Bynfezia An increased risk of QT interval prolongation Details Quinine Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Quinine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Quinine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Quinine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Quinine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Quinine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.