Ramelteon

23 interactions 2 explained in plain English
Also sold as: Rozerem
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Midazolam Nasal Spray Butorphanol Injection Butorphanol Nasal Spray Capmatinib Fentanyl Transdermal Patch
22 Major 1 Moderate
All (23) Major (22) Moderate (1)

Major

Ramelteon Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Ramelteon Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Ramelteon Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Ramelteon Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Ramelteon Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Ramelteon Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Ramelteon Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Ramelteon Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Ramelteon Diazepam Rectal Diastat Increased risk of CNS depression Details Ramelteon Esketamine Nasal Spray Spravato Increased risk of sedation Details Ramelteon Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Ramelteon Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Ramelteon Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Ramelteon Ketoconazole Topical Extina® Foam Increased ramelteon exposure and an increased risk of ramelteon-related adverse reactions Details Ramelteon Lacosamide Injection Motpoly An increased risk of CNS depression Details Ramelteon Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Ramelteon Metoclopramide Injection Gimoti Increased risk of CNS depression Details Ramelteon Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Ramelteon Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Ramelteon Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Ramelteon Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Ramelteon Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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