Ramipril

64 interactions 1 explained in plain English
Also sold as: Altace Altace® Vostally
About Ramipril

Ramipril is an ACE inhibitor used to treat high blood pressure and reduce heart attack and stroke risk. Read the full Ramipril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Ramipril Aspirin Acuprin® Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Ramipril Aspirin Rectal Aspirin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Ramipril Azathioprine Azasan An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Ramipril Azilsartan Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Ramipril Cyclosporine Injection Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Ramipril Cyclosporine Ophthalmic Cequa Acute renal dysfunction and an increased risk of hyperkalemia Details Ramipril Digoxin Cardoxin® An increased digoxin exposure Details Ramipril Eprosartan Teveten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Ramipril Everolimus Afinitor Increased risk of angioedema Details Ramipril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Ramipril Irbesartan Avapro Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Ramipril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Ramipril Losartan Arbli Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Ramipril Melphalan Alkeran An increased risk of severe hypotension Details Ramipril Melphalan Injection Alkeran An increased risk of severe hypotension Details Ramipril Mercaptopurine Purinethol® An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Ramipril Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ramipril Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.