Remifentanil

37 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Remifentanil Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Remifentanil Amitriptyline Elavil Explained Increased risk of serotonin syndrome Details Remifentanil Sertraline Explained Increased risk of serotonin syndrome Details Remifentanil Buprenorphine Belbuca Explained Increased risk of CNS and respiratory depression, profound sedation, hypotension, coma and death, reduced analgesic effect or prec... Details Remifentanil Aripiprazole Injection Abilify Increased risk of CNS depression and an increased risk of hypotension Details Remifentanil Asenapine Transdermal Patch Secuado Increased risk of CNS depression and an increased risk of hypotension Details Remifentanil Butorphanol Injection Butorphic Increased risk of CNS and respiratory depression, profound sedation, hypotension, coma and death, reduced analgesic effect or prec... Details Remifentanil Butorphanol Nasal Spray Stadol® NS Increased risk of CNS and respiratory depression, profound sedation, hypotension, coma and death, reduced analgesic effect or prec... Details Remifentanil Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Remifentanil Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Remifentanil Clopidogrel Plavix Reduced efficacy of clopidogrel Details Remifentanil Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Remifentanil Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Remifentanil Diphenhydramine Injection Banophen Increased risk of CNS depression and an increased risk of hypotension Details Remifentanil Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression and an increased risk of hypotension Details Remifentanil Dolasetron Anzemet Increased risk of serotonin syndrome Details Remifentanil Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Remifentanil Esketamine Nasal Spray Spravato Increased risk of sedation Details Remifentanil Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Remifentanil Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Remifentanil Granisetron Injection Granisol Increased risk of serotonin syndrome Details Remifentanil Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Remifentanil Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Remifentanil Hydroxychloroquine Plaquenil An increased risk of seizures Details Remifentanil Lacosamide Injection Motpoly An increased risk of CNS depression Details Remifentanil Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Remifentanil Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity Details Remifentanil Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Remifentanil Metoclopramide Injection Gimoti Increased risk of CNS depression Details Remifentanil Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Remifentanil Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Remifentanil Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Remifentanil Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Remifentanil Nalbuphine Injection Nubain® Increased risk of CNS and respiratory depression, profound sedation, hypotension, coma and death, reduced analgesic effect or prec... Details Remifentanil Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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