Risperidone and Olodaterol Oral Inhalation: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Olodaterol Oral Inhalation
Risperidone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias
Interaction Deep Dive
Beta-agonists have been reported to produce ECG changes, such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. Exert extreme caution when olodaterol (long acting beta-adrenergic agonist) is coadministered with drug that prolong QT interval as it may cause QT interval prolongation and increase the risk of ventricular arrhythmias1.
Why it happens (mechanism)
Additive QT interval prolongation
Literature reports
1 report — tap to read
a) Beta-agonists have been reported to produce ECG changes, such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression 1.
Common questions
Can I take Risperidone and Olodaterol Oral Inhalation together?
An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Always confirm with your pharmacist or prescriber before making any change.
How serious is the Risperidone and Olodaterol Oral Inhalation interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Risperidone or Olodaterol Oral Inhalation need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: STRIVERDI® RESPIMAT® inhalation spray, olodaterol inhalation spray. Boehringer Ingelheim Pharmaceuticals Inc (per DailyMed), Ridgefield, CT, 2025. DailyMed
Keep reading about Olodaterol Oral Inhalation
Keep reading about Risperidone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist