Rizatriptan

21 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Methylergonovine Dihydroergotamine Nasal Spray Dihydroergotamine Injection Palonosetron Injection Butorphanol Injection
4 Contraindicated 17 Major
All (21) Contraindicated (4) Major (17)

Major

Rizatriptan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Rizatriptan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Rizatriptan Sertraline Explained An increased risk of serotonin syndrome Details Rizatriptan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Rizatriptan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Rizatriptan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Rizatriptan Dolasetron Anzemet Increased risk of serotonin syndrome Details Rizatriptan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Rizatriptan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Rizatriptan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Rizatriptan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Rizatriptan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Rizatriptan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Rizatriptan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Rizatriptan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Rizatriptan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Rizatriptan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.