Rofecoxib
92 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac
Ketorolac Injection
Ketorolac Nasal Spray
Ketorolac Ophthalmic
Pemetrexed Injection
Aspirin
Contraindicated
Rofecoxib Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Rofecoxib Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Rofecoxib Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Rofecoxib Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) DetailsMajor
Rofecoxib Amitriptyline Elavil Explained An increased risk of bleeding Details Rofecoxib Sertraline Explained An increased risk of bleeding Details Rofecoxib Apixaban Eliquis Explained An increased risk of bleeding Details Rofecoxib Asenapine Transdermal Patch Secuado Increased asenapine exposure Details Rofecoxib Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Rofecoxib Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Rofecoxib Betrixaban Bevyxxa® An increased risk of bleeding Details Rofecoxib Anagrelide Agrylin An increased risk of bleeding Details Rofecoxib Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Rofecoxib Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Clopidogrel Plavix An increased risk of bleeding Details Rofecoxib Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Rofecoxib Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Rofecoxib Dabigatran Pradaxa® An increased risk of bleeding Details Rofecoxib Dabigatran Etexilate An increased risk of bleeding Details Rofecoxib Dalteparin Injection Fragmin An increased risk of bleeding Details Rofecoxib Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Rofecoxib Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Rofecoxib Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Rofecoxib Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Rofecoxib Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Rofecoxib Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Rofecoxib Dipyridamole Permole® An increased risk of bleeding Details Rofecoxib Edoxaban Savaysa An increased risk of bleeding Details Rofecoxib Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Rofecoxib Enoxaparin Lovenox An increased risk of bleeding Details Rofecoxib Enoxaparin Injection Lovenox An increased risk of bleeding Details Rofecoxib Epoprostenol Flolan An increased risk of bleeding Details Rofecoxib Etodolac Lodine Increased risk of bleeding Details Rofecoxib Fenoprofen Fenopron Increased risk of bleeding Details Rofecoxib Flurbiprofen Ansaid Increased risk of bleeding Details Rofecoxib Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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